Capture, detect & Preserve
[Inspired from intracellular DNA recognition pathways]
ZipPrime has developed a novel circulating free DNA (cfDNA) capturing and preservation technology as a complete and dedicated pre-analytical workflow for early disease diagnosis. Instead of size selection-based of cfDNA extraction methods, ZipPrime’s technology prevents the loss of cfDNAs and improves the accuracy of cfDNA-based clinical diagnosis by tagging each and every cfDNA fragment, including the very rare cfDNA biomarkers, at a single molecule level. ZipPrime’s patented cfDNA capturing and preservation technology also allow the reusable storage, enrichment and subsequent testing of captured cfDNA fragments by constructing a reusable cfDNA biomarker library without the need for complicated devices or protocols. This disruptive cfDNA manipulation workflow creates a reusable cfDNA biomarker library template of the captured cfDNA fragments, which can be amplified, sequenced and/or re-analysed with any PCR-based protocol whenever required, even after long-term storage.